Vinorelbine is a chemotherapy drug used to treat breast cancer. It’s also known by the brand name Navelbine.
How effective is Navelbine? A phase 2 clinical trial that is studying the effectiveness of navelbine (vinorelbine) as a single-agent first-line treatment is showing a partial response rate of 24%, a stable disease rate of 55% with 21% of patients experiencing disease progression during treatment.
Consequently, What type of chemo is vinorelbine? Drug type: Vinorelbine is an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. This medication is classified as a “plant alkaloid.” (For more detail, see “How this drug works” section below).
How often is Navelbine given?
The recommended dosage of NAVELBINE is 30 mg/m2 administered as an intravenous injection or infusion over 6 to 10 minutes once a week in combination with cisplatin 120 mg/m2 on Days 1 and 29, then every 6 weeks.
How do you take Navelbine?
Taking Navelbine soft capsule:
- Swallow Navelbine whole with water, preferably with a light meal. …
- Do not chew or suck the capsules.
- If you chew or suck a capsule by mistake, rinse your mouth thoroughly with water and tell your doctor immediately.
Likewise, Is Taxotere a good chemo drug? Because Taxotere is a strong chemotherapy drug, its side effects tend to be more extreme than drugs that treat less serious issues such as high cholesterol or blood pressure. Doctors may lower the dose or prescribe drugs that reduce the risk of allergic reactions to deal with these types of side effects.
What are the common side effects of carboplatin?
Stomach pain, body aches/pain, diarrhea, constipation, weakness, nausea, and vomiting may occur. Nausea and vomiting can be severe in some patients but usually go away within 24 hours of treatment. Drug therapy may be needed to prevent or relieve nausea and vomiting.
What are the side effects of cisplatin? Side Effects
- Black, tarry stools.
- blood in urine or stools.
- burning, numbness, tingling, or painful sensations.
- change in frequency of urination or amount of urine.
- cough or hoarseness.
- difficulty in breathing.
- feeling of fullness in the ears.
- fever or chills.
Is dexamethasone a steroid?
Dexamethasone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.
When does hair fall out with Taxotere? You may begin to lose your hair about two weeks after the first treatment, but it can happen earlier. Hair loss is usually gradual but it can happen very quickly, possibly over a couple of days. Scalp cooling may stop you losing some, or all, of the hair on your head.
Does hair grow back after Taxotere? In many cases, hair eventually returns to the way it used to be after the effect of chemotherapy on the hair follicle wears off. But some people have incomplete hair regrowth. And sometimes permanent baldness and loss of eyebrows and eyelashes can occur, particularly in people who received Taxotere.
Which is better Taxol or Taxotere?
Taxotere Versus Taxol
According to studies, Taxotere showed more benefits to survival than Taxol (paclitaxel), another chemotherapy drug in the same class. Researchers also found docetaxel was more cost effective.
Will I lose my hair with carboplatin?
v Hair loss is minimal with carboplatin, but some patients do experience more hair loss than others. Hair growth should return upon completion of treatment. v Nausea and vomiting are not unusual but are less common today than in the past because of much improved anti-nausea medications.
What is the success rate of carboplatin? The 5-year overall survival rates were 66% in cisplatin/vinorelbine group, 55% in carboplatin/vinorelbine group and 70% in cisplatin/vinorelbine/carboplatin/vinorelbine group ( p = 0, 95).
Do you gain weight on carboplatin?
Although there has not been a systematic analysis to date, there is some evidence that carboplatin combined with paclitaxel can cause weight gain in ovarian cancer patients. Therefore, there may be potential risk-factors related to survival related to either high BMI or weight loss.
Is cisplatin a strong chemo? Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical . In ovarian germ cell cancer, the use of cisplatin brings about high response rates .
What cancers are treated with cisplatin?
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.
What is the most common side effect of cisplatin? The following side effects are common (occurring in greater than 30%) for patients taking Cisplatin: Nausea and vomiting. Nausea may last up to 1 week after therapy. Anti-nausea medication is given before the infusion, and a prescription is also given for use after.
What is the side effect of dexamethasone?
Dexamethasone side effects
blurred vision, tunnel vision, eye pain, or seeing halos around lights; shortness of breath (even with mild exertion), swelling, rapid weight gain; severe depression, unusual thoughts or behavior; a seizure (convulsions);
Why is dexamethasone used in Covid? In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
How long can you stay on dexamethasone?
For some conditions you may only need to take dexamethasone for a few days or weeks. However, for other conditions you may need to take it for longer, sometimes for several months. Can I take dexamethasone for a long time? Taking dexamethasone for several months can increase the risk of some other side effects.
Do you lose your hair with Taxotere? Taxotere and Pacilitaxel are equally effective, but Taxotere has the added risk of permanent hair loss. Hair loss is typical with chemotherapy, but hair growth resumes shortly after treatments have finished.
Does hair grow back GREY after chemo?
This is due to the loss or change of pigment and may result in hair that is white, gray, or another color that is different from your natural hair. As your body recovers and hair pigment comes back, your hair may return to its original color or a color close to your pre-chemo hair.
What percentage of Taxotere patients have permanent hair loss? Taxotere manufacturer, Sanofi-Aventis, alleges that long-term alopecia–permanent hair loss–only occurs in about three percent of patients.
What is the alternative to Taxotere?
There is also evidence that Abraxane is able to deliver the chemotherapy drug more effectively to the tumor.” “These results suggest that weekly nab-paclitaxel may be an appropriate alternative to docetaxel (Taxotere) in the first-line treatment of patients with metastatic breast cancer,” Gradishar said.
Does pubic hair grow back after chemotherapy? The hairs on the scalp fall out first, and then a little later facial hair, body hair and pubic hair may fall out too. A few weeks after the end of chemotherapy, the hairs start to grow back in most people.
Does Taxotere cause weight gain?
If you notice swelling in the feet and legs or a slight weight gain, inform your doctor or nurse. Taxotere may cause fluid retention which means the body is holding extra water.